A recent discovery on early detection and prevention of blood cancer made by two independent research teams from Broad Institute of MIT and Harvard Medical School with Harvard Stem Cell Institute, opened new gates for easy detection of premaglinant state of blood. The recent findings published in the journal New England Journal of Medicine.

Till now all the recent research approaches made was based on genomes of advanced cancers, where the focus has been the genes that are mutated in various types of cancers. But in this research performed by two groups of researchers took a different approach of focusing on somatic mutations, i.e. the mutations that replicate and regenerate within the body. The participants here are not having cancer or any blood disorders, whose DNA were isolated from the blood.

The premaglinant state which is mentioned in the study were more common based on the age of the individual. It is much rare under age of 40, but the frequency increases as the life passes ahead and ultimately was found more about 10 percent increase in the chance of individuals over 70years. Carriers of the mutations are having at least 5 percent risk of obtaining any different type of blood cancer by five years. This premaglinant state was identified by simple sequencing technique of the DNA isolated from the blood.

The question does come that from where these mutations originate or develop. Actually the mutations originate in the blood stem cells and induce a growth promoting response to the mutated cells and all of its subordinate cells will develop from the original mutated cells. Thus the cells acquire the ability to divide at an accelerated rate until they acquire the entire reach of the blood. The researchers call them as “cooperating” mutations which drives the cell towards cancer. The majority of the mutations were found in three genes – DNMT3A, TET2 and ASXL1.

Check the Video, where Dr. Steven McCarroll and Dr. Benjamin Ebert the two leading researchers say about their identification.

Read Full Story at Harvard Research News 

Courtesy: Harvard Health and Medicine